Universidad Complutense de Madrid :: Neurobiología del desarrollo del SNC de los vertebrados

PUBLICACIONES CIENTÍFICAS

Viviani B, Boraso M, Valero M, Gardoni F, Marco EM, Llorente R, Corsini E, Galli CL, Di Luca M, Marinovich M, López-Gallardo M, Viveros MP. Early maternal deprivation immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I in a sex dependent manner. Brain Behav Immun. 2013 Sep 21. [Epub ahead of print]

Perianes-Cachero A, Burgos-Ramos E, Puebla-Jiménez L, Canelles S, Frago LM, Hervás-Aguilar A, de Frutos S, Lobo MV, Mela V, Viveros MP, Argente J, Chowen JA, Arilla-Ferreiro E, Barrios V. Acute up-regulation of the rat brain somatostatin receptor-effector system by leptin is related to activation of insulin signaling and may counteract central leptin actions. Neuroscience. 2013 [Epub ahead of print]

Lopez-Rodriguez AB, Siopi E, Finn DP, Marchand-Leroux C, Garcia-Segura LM, Jafarian-Tehrani M, Viveros MP.CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice. Cereb Cortex. 2013 Aug 19. [Epub ahead of print]

Burke NN, Llorente R, Marco EM, Tong K, Finn DP, Viveros MP, Roche M. Maternal Deprivation Is Associated With Sex-Dependent Alterations in Nociceptive Behavior and Neuroinflammatory Mediators in the Rat Following Peripheral Nerve Injury. J Pain. 2013 Jul 11. [Epub ahead of print]

Llorente-Berzal A, Assis MA, Rubino T, Zamberletti E, Marco EM, Parolaro D, Ambrosio E, Viveros MP.Sex-dependent changes in brain CB1R expression and functionality and immune CB2R expression as a consequence of maternal deprivation and adolescent cocaine exposure. Pharmacol Res. 2013, 74:23-33.

Marco EM, Valero M, de la Serna O, Aisa B, Borcel E, Ramirez MJ, Viveros MP. Maternal deprivation effects on brain plasticity and recognition memory in adolescent male and female rats. Neuropharmacology. 2013, 68:223-31.

Marco EM, Scattoni ML, Rapino C, Ceci C, Chaves N, Macrì S, Maccarrone M, Laviola G. Emotional, endocrine and brain anandamide response to social challenge in infant male rats. Psychoneuroendocrinology. 2013 May 6. [Epub ahead of print]

Llorente-Berzal A, Manzanedo C, Daza-Losada M, Valero M, López-Gallardo M, Aguilar MA, Rodríguez-Arias M, Miñarro J, Viveros MP. Sex-dependent effects of early maternal deprivation on MDMA-induced conditioned place preference in adolescent rats: Possible neurochemical correlates. Toxicology. 2013, 6;311(1-2):78-86.

Perianes-Cachero A, Burgos-Ramos E, Puebla-Jiménez L, Canelles S, Viveros MP, Mela V, Chowen JA, Argente J, Arilla-Ferreiro E, Barrios V. Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects. Neurochem Int. 2012 61(8):1385-96.

Mela V, Llorente-Berzal Á, Díaz F, Argente J, Viveros MP, Chowen JA. Maternal deprivation exacerbates the response to a high fat diet in a sexually dimorphic manner. PLoS One. 2012;7(11):e48915.

Rey AA, Purrio M, Viveros MP, Lutz B.Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Neuropsychopharmacology. 2012 37(12):2624-34. 

Marco EM, Romero-Zerbo SY, Viveros MP, Bermudez-Silva FJ. The role of the endocannabinoid system in eating disorders: pharmacological implications. Behav Pharmacol. 2012, 23(5-6):526-36.

Viveros MP, Mendrek A, Paus T, López-Rodríguez AB, Marco EM, Yehuda R, Cohen H, Lehrner A, Wagner EJ. A comparative, developmental, and clinical perspective of neurobehavioral sexual dimorphisms. Front Neurosci. 2012, 6:84.

Finn DP, Viveros MP, Marco EM. The endocannabinoid system and emotional processing: pathophysiology and therapeutic potential. J Psychopharmacol. 2012, 26(1):3-6.

Mela V, Díaz F, Gertler A, Solomon G, Argente J, Viveros MP, Chowen JA. Neonatal treatment with a pegylated leptin antagonist has a sexually dimorphic effect on hypothalamic trophic factors and neuropeptide levels. J Neuroendocrinol. 2012, 24(5):756-65.

Llorente R, Villa P, Marco EM, Viveros MP. Analyzing the effects of a single episode of neonatal maternal deprivation on metabolite profiles in rat brain: a proton nuclear magnetic resonance spectroscopy study. Neuroscience. 2012, 10;201:12-9.

López-Gallardo M, López-Rodríguez AB, Llorente-Berzal Á, Rotllant D, Mackie K, Armario A, Nadal R, Viveros MP. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience. 2012, 204:90-103.

Llorente-Berzal A, Mela V, Borcel E, Valero M, López-Gallardo M, Viveros MP, Marco EM. Neurobehavioral and metabolic long-term consequences of neonatal maternal deprivation stress and adolescent olanzapine treatment in male and female rats. Neuropharmacology. 2012, 62(3):1332-41.

Viveros MP, Llorente R, Suarez J, Llorente-Berzal A, López-Gallardo M, de Fonseca FR The endocannabinoid system in critical neurodevelopmental periods: sex differences and neuropsychiatric implications. J Psychopharmacol. 2012, 26(1):164-76.

Marco EM, Laviola G. The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives. J Psychopharmacol. 2012, 26: 150-163.   

 Quesada A, Aguilera Y, Caparrós R, Prada FA, Santano C, López-López R, Prada C. Myelin oligodendrocyte-specific protein is expressed in Müller cells of myelinated vertebrate retinas. J Neurosci Res. 2011, 89(5):674-88.

 Marco EM, Rapino C, Caprioli A, Borsini F, Maccarrone M, Laviola G. Social encounter with a novel partner in adolescent rats: activation of the central endocannabinoid system. Behav Brain Res. 2011, 220: 140-5.

Marco EM, Adriani W, Ruocco LA, Canese R, Sadile AG, Laviola G. Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure. Neurosci Biobehav Rev. 2011, 35: 1722-39.                 

Laviola G, Marco EM. Passing the knife edge in adolescence: brain pruning and specification of individual lines of development. Neurosci Biobehav Rev.  2011, 35: 1631-3.

Canese R, Marco EM, De Pasquale F, Podo F, Laviola G, Adriani W. Differential response to specific 5-Ht(7) versus whole-serotonergic drugs in rat forebrains: a phMRI study. Neuroimage. 2011, 58: 885-94.                    

Marco EM, García-Gutiérrez MS, Bermúdez-Silva FJ, Moreira FA, Guimarães F, Manzanares J, Viveros MP. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. Front Behav Neurosci. 2011;5:63.

Granado M, García-Cáceres C, Fuente-Martín E, Díaz F, Mela V, Viveros MP, Argente J, Chowen JA. Effects of acute changes in neonatal leptin levels on food intake and long-term metabolic profiles in rats. Endocrinology. 2011, 152(11):4116-26.

Onaivi ES, Benno R, Halpern T, Mehanovic M, Schanz N, Sanders C, Yan X, Ishiguro H, Liu QR, Berzal AL, Viveros MP, Ali SF. Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders. Curr Neuropharmacol. 2011, 9(1):209-14.

Llorente-Berzal A, Fuentes S, Gagliano H, López-Gallardo M, Armario A, Viveros MP, Nadal R. Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour. Addict Biol. 2011, 16(4):624-37.

López Rodríguez AB, Mateos Vicente B, Romero-Zerbo SY, Rodriguez-Rodriguez N, Bellini MJ, Rodriguez de Fonseca F, Bermudez-Silva FJ, Azcoitia I, Garcia-Segura LM, Viveros MP. Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors. Cereb Cortex. 2011, 21(9):2046-55.

Llorente R, Miguel-Blanco C, Aisa B, Lachize S, Borcel E, Meijer OC, Ramirez MJ, De Kloet ER, Viveros MP. Long term sex-dependent psychoneuroendocrine effects of maternal deprivation and juvenile unpredictable stress in rats. J Neuroendocrinol. 2011, 23(4):329-44.

Viveros MP, Marco EM, López-Gallardo M, Garcia-Segura LM, Wagner EJ. Framework for sex differences in adolescent neurobiology: a focus on cannabinoids. Neurosci Biobehav Rev. 2011, 35(8):1740-51

Mateos B, Borcel E, Loriga R, Luesu W, Bini V, Llorente R, Castelli MP, Viveros MP. Adolescent exposure to nicotine and/or the cannabinoid agonist CP 55,940 induces gender-dependent long-lasting memory impairments and changes in brain nicotinic and CB(1) cannabinoid receptors. J Psychopharmacol. 2011, 25(12):1676-90.

Marco EM, Macrì S, Laviola G. Critical age windows for neurodevelopmental psychiatric disorders: evidence from animal models. Neurotox Res. 2011, 19(2):286-307.

 Boije H, Ring H, López-Gallardo M, Prada C, Hallböök F. Pax2 is expressed in a subpopulation of Müller cells in the central chick retina. Dev Dyn. 2010, 239(6):1858-66.

Viveros MP, Llorente R, Díaz F, Romero-Zerbo SY, Bermudez-Silva FJ, Rodríguez de Fonseca F, Argente J, Chowen JA. Maternal deprivation has sexually dimorphic long-term effects on hypothalamic cell-turnover, body weight and circulating hormone levels. Horm Behav. 2010, 58(5):808-19

Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M. Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice. Rejuvenation Res. 2010, 13(4):415-28

Suárez J, Rivera P, Llorente R, Romero-Zerbo SY, Bermúdez-Silva FJ, de Fonseca FR, Viveros MP. Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus. Brain Res. 2010, 19;1349:162-73

Llorente R, O'Shea E, Gutierrez-Lopez MD, Llorente-Berzal A, Colado MI, Viveros MP. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats. Neurosci Lett. 2010, 26;479(2):112-7.

Bermudez-Silva FJ, Viveros MP, McPartland JM, Rodriguez de Fonseca F. The endocannabinoid system, eating behavior and energy homeostasis: the end or a new beginning? Pharmacol Biochem Behav. 2010, 95(4):375-82

Viveros MP, Díaz F, Mateos B, Rodríguez N, Chowen JA. Maternal deprivation induces a rapid decline in circulating leptin levels and sexually dimorphic modifications in hypothalamic trophic factors and cell turnover. Horm Behav. 2010, 57(4-5):405-14.

Alén F, Mouret A, Viveros MP, Llorente R, Lepousez G, Lledo PM, López-Moreno JA. Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. Int J Neuropsychopharmacol. 2010, 13(2):191-205.

Marco EM, Viveros MP. The critical role of the endocannabinoid system in emotional homeostasis: avoiding excess and deficiencies. Mini Rev Med Chem. 2009, 9(12):1407-15.

Fernandez-Espejo E, Viveros MP, Núñez L, Ellenbroek BA, Rodriguez de Fonseca F. Role of cannabis and endocannabinoids in the genesis of schizophrenia. Psychopharmacology 2009, 206(4):531-49.

Viveros MP, Llorente R, López-Gallardo M, Suarez J, Bermúdez-Silva F, De la Fuente M, Rodriguez de Fonseca F, Garcia-Segura LM. Sex-dependent alterations in response to maternal deprivation in rats. Psychoneuroendocrinology. 2009, 34 Suppl 1:S217-26.

Liu QR, Pan CH, Hishimoto A, Li CY, Xi ZX, Llorente-Berzal A, Viveros MP, Ishiguro H, Arinami T, Onaivi ES, Uhl GR. Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. Genes Brain Behav. 2009, 8(5):519-30

Llorente R, Gallardo ML, Berzal AL, Prada C, Garcia-Segura LM, Viveros MP. Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells. Int J Dev Neurosci. 2009, 27(3):233-41.

De la Fuente M, Llorente R, Baeza I, De Castro NM, Arranz L, Cruces J, Viveros MP. Early maternal deprivation in rats: a proposed animal model for the study of developmental neuroimmunoendocrine interactions. Ann N Y Acad Sci. 2009, 1153:176-83.

Marco EM, Viveros MP. Functional role of the endocannabinoid system in emotional homeostasis]. Rev Neurol. 2009, 1-15;48(1):20-6.

Marco EM, Rubino T, Adriani W, Viveros MP, Parolaro D, Laviola G. Long-term consequences of URB597 administration during adolescence on cannabinoid CB1 receptor binding in brain areas. Brain Res. 2009, 27;1257:25-31.

Suárez J, Llorente R, Romero-Zerbo SY, Mateos B, Bermúdez-Silva FJ, de Fonseca FR, Viveros MP. Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats. Hippocampus. 2009, 19(7):623-32.

Marco EM, Adriani W, Llorente R, Laviola G, Viveros MP. Detrimental psychophysiological effects of early maternal deprivation in adolescent and adult rodents: altered responses to cannabinoid exposure. Neurosci Biobehav Rev. 2009, 33(4):498-507.

Canese R, Adriani W, Marco EM, De Pasquale F, Lorenzini P, De Luca N, Fabi F, Podo F, Laviola G. Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study. Psychopharmacology 2009, 203(1):143-53. 

Leo D, Adriani W, Cavaliere C, Cirillo G, Marco EM, Romano E, di Porzio U, Papa M, Perrone-Capano C, Laviola G. Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. Genes Brain Behav. 2009, 8(3):356-68.

Viveros MP, de Fonseca FR, Bermudez-Silva FJ, McPartland JM. Critical role of the endocannabinoid system in the regulation of food intake and energy metabolism, with phylogenetic, developmental, and pathophysiological implications. Endocr Metab Immune Disord Drug Targets. 2008, 8(3):220-30.

López-Gallardo M, Llorente R, Llorente-Berzal A, Marco EM, Prada C, Di Marzo V, Viveros MP. Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation. Dev Neurobiol. 2008, 68(12):1429-40.

Llorente R, Llorente-Berzal A, Petrosino S, Marco EM, Guaza C, Prada C, López-Gallardo M, Di Marzo V, Viveros MP. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: a possible role for the endocannabinoid system. Dev Neurobiol. 2008, 15;68(11):1334-47.

López-López R, López-Gallardo M, Pérez-Alvarez MJ, Prada C. Isolation of chick retina cones and study of their diversity based on oil droplet colour and nucleus position. Cell Tissue Res. 2008, 332(1):13-24

Biscaia M, Fernández B, Higuera-Matas A, Miguéns M, Viveros MP, García-Lecumberri C, Ambrosio E. Sex-dependent effects of periadolescent exposure to the cannabinoid agonist CP-55,940 on morphine self-administration behaviour and the endogenous opioid system. Neuropharmacology. 2008, 54(5):863-73.

Lamota L, Bermudez-Silva FJ, Marco EM, Llorente R, Gallego A, Rodríguez de Fonseca F, Viveros MP. Effects of adolescent nicotine and SR 147778 (Surinabant) administration on food intake, somatic growth and metabolic parameters in rats. Neuropharmacology. 2008, 54(1):194-205.

Viveros MP, Arranz L, Hernanz A, Miquel J, De la Fuente M. A model of premature aging in mice based on altered stress-related behavioral response and immunosenescence. Neuroimmunomodulation. 2007,14(3-4):157-62

Viveros MP, Marco EM, Llorente R, Lamota L. The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions. Behav Pharmacol. 2007, 18(5-6):375-89.

Viveros MP, Marco EM, Llorente R, López-Gallardo M. Endocannabinoid system and synaptic plasticity: implications for emotional responses. Neural Plast. 2007. Article ID 52908, 12 pages.

Llorente R, Arranz L, Marco EM, Moreno E, Puerto M, Guaza C, De la Fuente M, Viveros MP. Early maternal deprivation and neonatal single administration with a cannabinoid agonist induce long-term sex-dependent psychoimmunoendocrine effects in adolescent rats. Psychoneuroendocrinology. 2007, 32(6):636-50.

Zambrana C, Marco EM, Arranz L, de Castro NM, Viveros MP, de la Fuente M. Influence of aging and enriched environment on motor activity and emotional responses in mice. Ann N Y Acad Sci. 2007, 1100:543-52.

Marco EM, Granstrem O, Moreno E, Llorente R, Adriani W, Laviola G, Viveros MP. Subchronic nicotine exposure in adolescence induces long-term effects on hippocampal and striatal cannabinoid-CB1 and mu-opioid receptors in rats. Eur J Pharmacol. 2007, 14;557(1):37-43.

Marco EM, Adriani W, Canese R, Podo F, Viveros MP, Laviola G. Enhancement of endocannabinoid signalling during adolescence: Modulation of impulsivity and long-term consequences on metabolic brain parameters in early maternally deprived rats. Pharmacol Biochem Behav. 2007, 86(2):334-45.

Viveros MP, Marco EM, File SE. Nicotine and cannabinoids: parallels, contrasts and interactions. Neurosci Biobehav Rev. 2006, 30(8):1161-81.

Marco EM, Llorente R, Moreno E, Biscaia JM, Guaza C, Viveros MP. Adolescent exposure to nicotine modifies acute functional responses to cannabinoid agonists in rats. Behav Brain Res. 2006, 15;172(1):46-53.

López R, López-Gallardo M, Busturia I, Anezary L, Prada C. Spatial and temporal patterns of growth and differentiation of cone oil droplets in the chick retina. J Neurosci Res. 2005, 1;79(3):401-11.

Viveros MP, Llorente R, Moreno E, Marco EM. Behavioural and neuroendocrine effects of cannabinoids in critical developmental periods. Behav Pharmacol. 2005, 16(5-6):353-62.

Valenti M, Cottone E, Martinez R, De Pedro N, Rubio M, Viveros MP, Franzoni MF, Delgado MJ, Di Marzo V. The endocannabinoid system in the brain of Carassius auratus and its possible role in the control of food intake. J Neurochem. 2005, 95(3):662-72.

Martínez-Orgado J, Fernández-Frutos B, González R, Fernández-López D, Urigüen L, Romero E, Moro M, Bonet B, Viveros MP. Neuroprotective effect of L-arginine in a newborn rat model of acute severe asphyxia. Biol Neonate. 2005, 88(4):291-8.

Marco EM, Llorente R, Pérez-Alvarez L, Moreno E, Guaza C, Viveros MP. The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety. Behav Brain Res. 2005, 8;163(2):212-8

Pérez-Alvarez L, Baeza I, Arranz L, Marco EM, Borcel E, Guaza C, Viveros MP, De la Fuente M. Behavioral, endocrine and immunological characteristics of a murine model of premature aging. Dev Comp Immunol. 2005, 29(11):965-76.

Viveros MP, Marco EM, File SE. Endocannabinoid system and stress and anxiety responses. Pharmacol Biochem Behav. 2005, 81(2):331-42.

Quesada A, Prada FA, Aguilera Y, Espinar A, Carmona A, Prada C. Peripapillary glial cells in the chick retina: A special glial cell type expressing astrocyte, radial glia, neuron, and oligodendrocyte markers throughout development. Glia. 2004, 46(4):346-55.

Borcel E, Pérez-Alvarez L, de Ceballos ML, Ramirez BG, Marco EM, Fernández B, Rubio M, Guaza C, Viveros MP. Functional responses to the cannabinoid agonist WIN 55,212-2 in neonatal rats of both genders: influence of weaning. Pharmacol Biochem Behav. 2004, 78(3):593-602.

Marco EM, Pérez-Alvarez L, Borcel E, Rubio M, Guaza C, Ambrosio E, File SE, Viveros MP. Involvement of 5-HT1A receptors in behavioural effects of the cannabinoid receptor agonist CP 55,940 in male rats. Behav Pharmacol. 2004, 15(1):21-7.

Genn RF, Tucci S, Marco EM, Viveros MP, File SE. Unconditioned and conditioned anxiogenic effects of the cannabinoid receptor agonist CP 55,940 in the social interaction test. Pharmacol Biochem Behav. 2004, 77(3):567-73.

Biscaia M, Marín S, Fernández B, Marco EM, Rubio M, Guaza C, Ambrosio E, Viveros MP. Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood. Psychopharmacology (Berl). 2003, 170(3):301-8.

Martínez-Orgado J, Fernández-Frutos B, González R, Romero E, Urigüen L, Romero J, Viveros MP. Neuroprotection by the cannabinoid agonist WIN-55212 in an in vivo newborn rat model of acute severe asphyxia. Brain Res Mol Brain Res. 2003, 10;114(2):132-9.

De la Fuente M, Hernanz A, Medina S, Guayerbas N, Fernández B, Viveros MP. Characterization of monoaminergic systems in brain regions of prematurely ageing mice. Neurochem Int. 2003, 43(2):165-72.

Tucci S, Genn RF, Marco E, File SE. Do different mechanisms underlie two anxiogenic effects of systemic nicotine? Behav Pharmacol. 2003 Jul;14(4):323-9.

Marín S, Marco E, Biscaia M, Fernández B, Rubio M, Guaza C, Schmidhammer H, Viveros MP. Involvement of the kappa-opioid receptor in the anxiogenic-like effect of CP 55,940 in male rats. Pharmacol Biochem Behav. 2003, 74(3):649-56.

Romero EM, Fernández B, Sagredo O, Gomez N, Urigüen L, Guaza C, De Miguel R, Ramos JA, Viveros MP. Antinociceptive, behavioural and neuroendocrine effects of CP 55,940 in young rats. Brain Res Dev Brain Res. 2002, 30;136(2):85-92.

Urigüen L, Fernández B, Romero EM, De Pedro N, Delgado MJ, Guaza C, Schmidhammer H, Viveros MP. Effects of 14-methoxymetopon, a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity in male rats: neuroendocrine correlates. Brain Res Bull. 2002, 15;57(5):661-6.