Universidad Complutense de Madrid :: Grupo de Investigación de Fisiología endocrina y envejecimiento

Publicaciones

1. Valero-Muñoz M, Martín-Fernández B, Ballesteros S, Martínez-Martínez E, Blanco-Rivero J, Balfagón G, Cachofeiro V, Lahera V, de las Heras N. Relevance of vascular PGC-1α in molecular alterations in atherosclerosis. Exp Physiol. 2013 Feb 1. [Epub ahead of print]
2. de las Heras N, Valero-Muñoz M, Ballesteros S, Gómez-Hernández A, Martín- Fernández B, Blanco-Rivero J, Cachofeiro V, Benito M, Balfagón G, Lahera V. Rosuvastatin induces insulin sensitization in rats fed a high fat diet: Role of adipose tissue SIRT-1 and stress signaling pathways. Nutr Metab Cardiovasc Dis. 2013 Feb 20. doi: pii: S0939-4753(12)00279-7. 10.1016/j.numecd.2012.11.009.
3. Laurent C, Maria M, Pascal R, Victoria C, Ernesto MM, de Boer RA, Françoise P, Patrick L, Faiez Z, Patrick R, Natalia LA. Galectin-3 mediates aldosterone-induced vascular fibrosis. Arteioscler Thromb Vasc Biol 2012 Nov 1 [Epub ahead of print]
4. Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C. Cardiotrophin-1 induces sarcoplasmic reticulum Ca2+ leak and arrhythmogenesis in adult rat ventricular myocytes. Cardiovasc Res. 2012 Oct 1;96(1):81-9. Epub 2012 Jul 11. PubMed PMID: 22787135.
5. Muñoz-Pacheco P, Ortega-Hernández A, Miana M, Cachofeiro V, Fernández-Cruz A, Gómez-Garre D. Ezetimibe inhibits PMA-induced monocyte/macrophage differentiation by altering microRNA expression: a novel anti- therosclerotic mechanism. Pharmacol Res. 2012 Sep 15. pii: S1043- 618(12)00169-7
6. Roque FR, Briones AM, García-Redondo AB, Galán M, Martínez-Revelles S, Avendaño MS, Cachofeiro V, Fernandes T, Vassallo DV, Oliveira EM, Salaices M. Aerobic exercise reduces oxidative stress and improves vascular changes of small  mesenteric and coronary arteries in hypertension. Br J Pharmacol. 2012 Sep 21. doi: 10.1111/j.1476-5381.2012.02224.x. [Epub ahead of print] PubMed PMID: 22994554.
7. Fernandez Juarez G, Luño J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M, Cachofeiro V, Nieto J, Fernández Vega F, Tato A, Gutierrez E; PRONEDI Study Group. Effect of Dual Blockade of the Renin-Angiotensin System on the Progression of Type 2 Diabetic Nephropathy: A Randomized Trial. Am J Kidney Dis. 2012 Aug 28. [Epub ahead of print] PubMed PMID: 22939518.
8. Sastre E, Blanco-Rivero J, Caracuel L, Lahera V, Balfagón G. Effects of lipopolysaccharide on the neuronal control of mesenteric vascular tone in rats: mechanisms involved. Shock. 2012 Aug;38(3):328-34. PubMed PMID: 22744306.
9. Bartolomé MV, San Román JA, Cordova C, Lahera V, Nieto ML, Cachofeiro  V. DIOL triterpenes block profibrotic effects of angiotensin II and protect from  cardiac hypertrophy. PLoS One. 2012;7(7):e41545. Epub 2012 Jul 23. PubMed PMID: 22844495; PubMed Central PMCID: PMC3402387.
10. de las Heras N, Aller MA, Arias J, Lahera V. The risk association between experimental portal hypertension and an aortic atherosclerosis-like disease. Hepatology. 2012 Jun 22. doi: 10.1002/hep.25917. [Epub ahead of print] PubMed PMID: 22730048.
11. Modrego J, de Las Heras N, Zamorano-León JJ, Mateos-Cáceres PJ, Martín-Fernández B, Valero-Muñoz M, Lahera V, López-Farré AJ. Changes in cardiac energy metabolic pathways in overweighed rats fed a high-fat diet. Eur J Nutr. 2012 Jun 14. [Epub ahead of print] PubMed PMID: 22695689.
12. de Las Heras N, Aller MA, Martín-Fernández B, Miana M, Ballesteros S, Regadera J, Cachofeiro V, Arias J, Lahera V. A wound-like inflammatory aortic response in chronic portal hypertensive rats. Mol Immunol. 2012 Jun;51(2):177-87. Epub 2012 Mar 29. PubMed PMID: 22463791.
13. Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Valero-Muñoz M, Vassallo D, Davel AP, Rossoni LV, Cachofeiro V, Lahera V. Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of serum- and glucocorticoid-regulated kinase type 1. Exp Physiol. 2012 Jun;97(6):710-8. Epub 2012 Feb 10. PubMed PMID: 22327331.
14. Gómez-Hernández A, Otero YF, de las Heras N, Escribano O, Cachofeiro V, Lahera V, Benito M. Brown fat lipoatrophy and increased visceral adiposity through a concerted adipocytokines overexpression induces vascular insulin resistance and dysfunction. Endocrinology. 2012 Mar;153(3):1242-55. Epub 2012 Jan 17. PubMed PMID: 22253415.
15. Aller MA, de las Heras N, Blanco-Rivero J, Arias JI, Lahera V, Balfagón G, Arias J. Portal hypertensive cardiovascular pathology: the rescue of ancestral survival mechanisms? Clin Res Hepatol Gastroenterol. 2012 Feb;36(1):35-46. Epub 2012 Jan 20. PubMed PMID: 22264837.
16. Alvarez G, Visitación Bartolomé M, Miana M, Jurado-López R, Martín R, Zuluaga  P, Martinez-Martinez E, Nieto ML, Alvarez-Sala LA, Millán J, Lahera V, Cachofeiro V. The effects of adiponectin and leptin on human endothelial cell proliferation: a live-cell study. J Vasc Res. 2012;49(2):111-22. doi: 10.1159/000332332. Epub 2012 Jan 13. PubMed PMID: 22249107.
17. Luaces M, Cachofeiro V, García-Muñoz-Najar A, Medina M, González N, Cancer E,  Rodríguez-Robles A, Cánovas G, Antequera-Pérez A. Anatomical and functional alterations of the heart in morbid obesity. Changes after bariatric surgery. Rev  Esp Cardiol (Engl). 2012 Jan;65(1):14-21. Epub 2011 Oct 19. English, Spanish. PubMed PMID: 22015018.
18. Martín R, Miana M, Jurado-López R, Martínez-Martínez E, Gómez-Hurtado N, Delgado C, Rossoni LV, Oliveira RA, Caffaro RR, Miana M, Sanz-Rosa D, Koike MK, Do Amaral SL, Michelini LC, Lahera V, Cachofeiro V. Cardiac benefits of exercise training in aging spontaneously hypertensive rats. J Hypertens. 2011 Dec;29(12):2349-58. PubMed PMID: 22045123.
19. López-Andrés N, Martin-Fernandez B, Rossignol P, Zannad F, Lahera V, Fortuno MA, Cachofeiro V, Díez J. A role for cardiotrophin-1 in myocardial remodelling induced by aldosterone. Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2372-82. Epub 2011 Sep 16. PubMed PMID: 21926338.
20. Lahera V, Cachofeiro V, de Las Heras N. Interplay of hypertension, inflammation, and angiotensin II. Am J Hypertens. 2011 Oct;24(10):1059. doi: 10.1038/ajh.2011.142. PubMed PMID: 21927010.
21. Furieri LB, Fioresi M, Junior RF, Bartolomé MV, Fernandes AA, Cachofeiro V, Lahera V, Salaices M, Stefanon I, Vassallo DV. Exposure to low mercury concentration in vivo impairs myocardial contractile function. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):193-9. Epub 2011 Jun 24. PubMed PMID: 21723307.
22. Guadall A, Orriols M, Alcudia JF, Cachofeiro V, Martinez-Gonzalez J, Rodriguez C. Hypoxia-induced ROS signaling is required for LOX up-regulation in endothelial cells. Front Biosci (Elite Ed). 2011 Jun 1;3:955-67. PubMed PMID: 21622104.
23. Lopez-Jaramillo P, Lahera V, Lopez-Lopez J. Epidemic of cardiometabolic diseases: a Latin American point of view. Ther Adv Cardiovasc Dis. 2011 Apr;5(2):119-31. Epub 2011 Mar 15. Review. PubMed PMID: 21406494.
24. Furieri LB, Galán M, Avendaño MS, García-Redondo AB, Aguado A, Martínez S, Cachofeiro V, Bartolomé MV, Alonso MJ, Vassallo DV, Salaices M. Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species. Br J Pharmacol. 2011 Apr;162(8):1819-31. doi: 10.1111/j.1476-5381.2011.01203.x. PubMed PMID: 21232032; PubMed Central PMCID: PMC3081124.
25. Miana M, de Las Heras N, Rodriguez C, Sanz-Rosa D, Martin-Fernandez B, Mezzano S, Lahera V, Martinez-Gonzalez J, Cachofeiro V. Effect of eplerenone on hypertension-associated renal damage in rats: potential role of Peroxisome proliferator activated receptor gamma (PPAR-γ). J Physiol Pharmacol. 2011 Feb;62(1):87-94. PubMed PMID: 21451213.
26. Martín-Fernández B, de las Heras N, Miana M, Ballesteros S, Delgado C, Song S, Hintze T, Cachofeiro V, Lahera V. Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression. J Cardiovasc Pharmacol. 2011 Jan;57(1):114-21. PubMed PMID: 20980916.
27. Blanco-Rivero J, de las Heras N, Martín-Fernández B, Cachofeiro V, Lahera V, Balfagón G. Rosuvastatin restored adrenergic and nitrergic function in mesenteric arteries from obese rats. Br J Pharmacol. 2011 Jan;162(1):271-85. doi: 10.1111/j.1476-5381.2010.01030.x. PubMed PMID: 20840472; PubMed Central PMCID: PMC3012421.
28. Smani T, Calderón-Sanchez E, Gómez-Hurtado N, Fernández-Velasco M, Cachofeiro V, Lahera V, Ordoñez A, Delgado C. Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes. Cardiovasc Res. 2010 Aug 1;87(3):459-66. Epub 2010 Feb 26. PubMed PMID: 20189952.
29. Zamorano-León JJ, Modrego J, Mateos-Cáceres PJ, Macaya C, Martín-Fernández B, Miana M, de las Heras N, Cachofeiro V, Lahera V, López-Farré AJ. A proteomic approach to determine changes in proteins involved in the myocardial metabolism in left ventricles of spontaneously hypertensive rats. Cell Physiol Biochem. 2010;25(2-3):347-58. Epub 2010 Jan 12. PubMed PMID: 20110695.
30. Rueda-Clausen CF, Lahera V, Calderón J, Bolivar IC, Castillo VR, Gutiérrez M, Carreño M, Oubiña Mdel P, Cachofeiro V, López-Jaramillo P. The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors. Int J Cardiol. 2010 Feb 18;139(1):32-41. Epub 2008 Oct 14. PubMed PMID: 18922591.
31. Calderón-Sanchez E, Delgado C, Ruiz-Hurtado G, Domínguez-Rodríguez A, Cachofeiro V, Rodríguez-Moyano M, Gomez AM, Ordóñez A, Smani T. Urocortin induces positive inotropic effect in rat heart. Cardiovasc Res. 2009 Sep 1;83(4):717-25.  Epub 2009 May 21. PubMed PMID:19460778.
32. de las Heras N, Martín-Fernández B, Miana M, Ballesteros S, Oubiña MP, López-Farré AJ, Cachofeiro V, Lahera V. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of leptin-adiponectin imbalance. J Hypertens Suppl. 2009 Aug;27(6):S37-41. PubMed PMID: 19633450.
33. Martin-Fernandez B, Miana M, De Las Heras N, Ruiz-Hurtado G, Fernandez-Velasco M, Bas M, Ballesteros S, Lahera V, Cachofeiro V, Delgado C. Cardiac L-type calcium current is increased in a model of hyperaldosteronism in the rat. Exp Physiol. 2009 Jun;94(6):675-83. Epub 2009 Apr 24. PubMed PMID: 19395659.
34. Rueda-Clausen CF, López-Jaramillo P, Luengas C, del Pilar Oubiña M, Cachofeiro V, Lahera V. Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects. Mediators Inflamm. 2009:469169. Epub 2009 Jun 23. PubMed PMID: 19584917; PubMed Central PMCID: PMC2702507.
35. Cachofeiro V, Goicochea M, de Vinuesa SG, Oubiña P, Lahera V, Luño J. Oxidative stress and inflammation, a link between chronic kidney disease and cardiovascular disease. Kidney Int Suppl. 2008 Dec;(111):S4-9. Review. PubMed PMID: 19034325.
36. Fukuda LE, Davel AP, Verissimo-Filho S, Lopes LR, Cachofeiro V, Lahera V, Rossoni LV. Fenofibrate and pioglitazone do not ameliorate the altered vascular reactivity in aorta of isoproterenol-treated rats. J Cardiovasc Pharmacol. 2008 Nov;52(5):413-21. PubMed PMID: 19033820.
37. Barrios V, Escobar C, Calderon A, Lahera V. N-acetylcysteine for the prevention of atrial fibrillation: beyond its antioxidant effect. Eur Heart J. 2008 Nov;29(22):2822-3; author reply 2823. Epub 2008 Oct 2. PubMed PMID: 18832774.
38. Wiggers GA, Peçanha FM, Briones AM, Pérez-Girón JV, Miguel M, Vassallo DV, Cachofeiro V, Alonso MJ, Salaices M. Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1033-H1043. Epub 2008 Jul 3. PubMed  PMID: 18599595.
39. Cachofeiro V, Miana M, de Las Heras N, Martín-Fernández B, Ballesteros S, Fernández-Tresguerres J, Lahera V. Aldosterone and the vascular system. J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):331-5. Epub 2008 Mar 6. Review. PubMed PMID: 18400490.
40. Davel AP, Fukuda LE, De Sá LL, Munhoz CD, Scavone C, Sanz-Rosa D, Cachofeiro  V, Lahera V, Rossoni LV. Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H211-9. Epub 2008 May 16. PubMed PMID: 18487443.
41. Lahera V, Cachofeiro V. Specific amelioration of cerebral endothelial dysfunction in hypertensive patients treated with atorvastatin. Am J Hypertens. 2008 Jun;21(6):604. PubMed PMID: 18500327.
42. Alvarez-Sala LA, Cachofeiro V, Masana L, Suarez C, Pinilla B, Plana N, Trias  F, Moreno MA, Gambus G, Lahera V, Pintó X. Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study. Clin Ther. 2008 Jan;30(1):84-97. PubMed PMID: 18343245.
43. Alvarez-Sala LA, Cachofeiro V, Masana L, Suarez C, Pinilla B, Plana N, Trias F, Moreno MA, Gambus G, Lahera V, Pintó X. Effects of fluvastatin extended-release (80 mg) alone and in combination with ezetimibe (10 mg) on low-density lipoprotein cholesterol and inflammatory parameters in patients with primary hypercholesterolemia: a 12-week, multicenter, randomized, open-label, parallel-group study. Clin Ther. 2008 Jan;30(1):84-97. PubMed PMID: 18343245.