Medicinal Chemistry Lab
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Research
Here you’ll find detailed information on our main research areas. Follow the links and learn more about each one of them.
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Cancer
Cancer is recognized as one of the main leading causes of death worldwide. Among all the processes involved in the cell cycle, mitogenic signal transduction, and to what extent it is modified in cancer cells, has turned out to be one of the most appealing research goals for oncology in recent years. Thereof, the design of small molecules able to interfere with these pathways may help in understanding more in depth their actual physiology, while providing us with new antiproliferative agents as well.
We have several ongoing projects aimed at developing new antitumour agents by blocking some of the regulatory cascades involved in tumour events.  [Learn more]

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Central Nervous System
We have designed and developed new serotoninergic agents and we have determined their affinity for the receptors involved in physiopathological processes such as craneoencefalic traumatism, isquemic ictus, migraine, cognitive disorders or psychiatric alterations including anxiety and depression. We also work in the design and development of new cannabinoid agents. We determine their affinity and activity for the different targets that constitute the endogenous cannabinoid system as well as the potential therapeutic application of these compounds.
Our research methodology comprises the hit identification, the hit to lead, and the lead optimization processes.  [Learn more]

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Antibiotics
The discovery and development of antibiotics are considered one of the most important medical advances of the past century. However, with the increase in antibiotic-resistant strains of pathogenic bacteria and emerging novel pathogens, there is a need for new antibacterial agents which act through novel mechanisms of action.  [Learn more]

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Development of new tools for biological and medicinal chemistry
The identification of additional therapeutic targets and the development of new molecular entities able to generate novel drugs currently represent two critical points in the deficiency of innovative therapeutic strategies. In this context, chemical biology comes up as the appropriate complement to medicinal chemistry, since it allows the development of forward chemical genomics, an approach based on the generation of new chemical tools for the study of the biological system and eventually, the validation and identification of therapeutic targets.
Based on these considerations, we have started a research line aimed at the development of probes for GPCR labelling and for the de novo study of ligand selectivity using proteomic strategies. [Learn more]

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